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| Reactivity: | Human, Mouse, Rat |
| Applications: | WB, FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal antibody |
| Gene Name: | Menin 1 |
| Gene Symbol: | MEN1 |
| Synonyms: | MEAI; SCG2 |
| Gene ID: | 4221 |
| UniProt ID: | O00255 |
| Clone ID: | 25GB2590 |
| Immunogen: | A synthesized peptide derived from human Menin |
| Dilution: | WB 1:4,000-1:20,000; FC 1:2,000 |
| Purification Method: | Affinity purified |
| Concentration: | Lot dependent |
| Buffer: | PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
Background
The gene MEN1 encodes menin, a tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. Menin is a scaffold protein that functions in histone modification and epigenetic gene regulation. It is thought to regulate several pathways and processes by altering chromatin structure through the modification of histones.
Images
 | Western blotting analysis using anti-menin 1 antibody (Cat#61463). Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-menin 1 antibody (Cat#61463, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using FeQ™ ECL Substrate Kit (Cat#226). |
 | Western blotting analysis using anti-menin 1 antibody (Cat#61463). Menin 1 expression in wild type (WT) and menin 1 (MEN1) knockdown (KD) HSHC cells with 20 μg of total cell lysates. Hsp90 α serves as a loading control. The blot was incubated with anti-menin 1 antibody (Cat#61463, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716). |
 | Flow cytometric analysis of Menin 1 expression in HepG2 cells using anti-Menin 1 antibody (Cat#61463, 1:2,000). Green, isotype control; red, Menin 1. |
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