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| Reactivity: | Human, Mouse, Rat |
| Applications: | WB, FC, IC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal antibody |
| Gene Name: | mannose receptor C-type 1 |
| Gene Symbol: | MRC1 |
| Synonyms: | MMR; hMR; CD206; MRC1L1; CLEC13D; CLEC13DL; bA541I19.1 |
| Gene ID: | 4360 |
| UniProt ID: | P22897 |
| Clone ID: | 25GB2060 |
| Immunogen: | A synthesized peptide derived from human MRC1 |
| Dilution: | WB 1:1,000-1:5,000; FC 1:2,000; IC 1:100-1:1,000 |
| Purification Method: | Affinity purified |
| Concentration: | Lot dependent |
| Buffer: | PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
Background
The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.
Images
 | Western blotting analysis using anti-mannose receptor (CD206) antibody (Cat#61279). Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-mannose receptor (CD206) antibody (Cat#61279, 1:5,000) and HRP-conjugated goat anti rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716). |
 | Western blotting analysis using anti-mannose receptor (CD206) antibody (Cat#61279). Mannose receptor (CD206) expression in wild-type (WT) and MRC1 knockdown (KD) HeLa cells with 20 μg of total cell lysates. Hsp90 α serves as a loading control. The blot was incubated with anti-mannose receptor (CD206) antibody (Cat#61279, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716). |
 | Flow cytometric analysis of Mannose Receptor (CD206) expression in HepG2 cells using Mannose Receptor (CD206) antibody (Cat#61279, 1:2,000). Green, isotype control; red, Mannose Receptor (CD206). |
 | lmmunocytochemical staining of HepG2 cells with Mannose Receptor (CD206) antibody (Cat#61279, 1:1,000). Nuclei were stained blue with DAPl; Mannose Receptor (CD206) was stained magenta with Alexa Fluor® 647. lmages were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: High. Scale bar, 20 μm. |
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