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| Reactivity: | Human, Mouse, Rat |
| Applications: | WB, FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal antibody |
| Gene Name: | phospholipid scramblase 1 |
| Gene Symbol: | PLSCR1 |
| Synonyms: | MMTRA1B |
| Gene ID: | 5359 |
| UniProt ID: | O15162 |
| Clone ID: | 24GB1550 |
| Immunogen: | A synthesized peptide derived from human Scramblase 1 |
| Dilution: | WB 1:1,000-1:5,000; FC 1:2,000 |
| Purification Method: | Affinity purified |
| Concentration: | Lot dependent |
| Buffer: | PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
Background
This gene encodes a phospholipid scramblase family member. The encoded protein is involved in disruption of the asymmetrical distribution of phospholipids between the inner and outer leaflets of the plasma membrane, resulting in externalization of phosphatidylserine. This cell membrane disruption plays an important role in the blood coagulation cascade as well as macrophage clearing of apoptotic cells. The encoded protein has additionally been implicated in gene regulation and interferon-induced antiviral responses.
Images
 | Western blotting analysis using anti-Phospholipid scramblase 1 antibody (Cat#62592). Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-Phospholipid scramblase 1 antibody (Cat#62592, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using FeQ™ ECL Substrate Kit (Cat#226). |
 | Western blotting analysis using anti-Phospholipid scramblase 1 antibody (Cat#62592). Phospholipid scramblase 1 expression in wild type (WT) and Phospholipid scramblase 1 shRNA knockdown (KD) HeLa cells with 20 μg of total cell lysates . β-Tubulin serves as a loading control. The blot was incubated with anti-Phospholipid scramblase 1 antibody (Cat#62592, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716). |
 | Flow cytometric analysis of Phospholipid scramblase 1 expression in HT-1080 cells using anti-Phospholipid scramblase 1 antibody (Cat#62592, 1:2,000). Green, isotype control; red, Phospholipid scramblase 1. |
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