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| Reactivity: | Human |
| Applications: | WB, FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal antibody |
| Gene Name: | paraoxonase 2 |
| Gene Symbol: | PON2 |
| Synonyms: | Serum paraoxonase/arylesterase 2; PON 2; Aromatic esterase 2; A-esterase 2; Serum aryldialkylphosphatase 2 |
| Gene ID: | 5445 |
| UniProt ID: | Q15165 |
| Clone ID: | 24GB1035 |
| Immunogen: | A synthesized peptide derived from human PON2 |
| Dilution: | WB 1:1,000-1:5,000; FC 1:2,000 |
| Purification Method: | Affinity purified |
| Concentration: | Lot dependent |
| Buffer: | PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
Background
This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.
Images
 | Western blotting analysis using anti-Paraoxonase 2 antibody (Cat#62478). Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-Paraoxonase 2 antibody (Cat#62478, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using FeQ™ ECL Substrate Kit (Cat#226). |
 | Western blotting analysis using anti-Paraoxonase 2 antibody (Cat#62478). Paraoxonase 2 expression in wild type (WT) and Paraoxonase 2 shRNA knockdown (KD) HeLa cells with 20 μg of total cell lysates . Hsp90 α serves as a loading control. The blot was incubated with anti-Paraoxonase 2 antibody (Cat#62478, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716). |
 | Flow cytometric analysis of Paraoxonase 2 expression in HepG2 cells using anti-Paraoxonase 2 antibody (Cat#62478, 1:2,000). Green, isotype control; red, Paraoxonase 2. |
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