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| Reactivity: | Human, Mouse, Rat |
| Applications: | WB, IC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal antibody |
| Gene Name: | retinoic acid receptor alpha |
| Gene Symbol: | RARA |
| Synonyms: | RAR; NR1B1; RARalpha |
| Gene ID: | 5914 |
| UniProt ID: | P10276 |
| Clone ID: | 24GB1160 |
| Immunogen: | A synthesized peptide derived from human Retinoic Acid Receptor alpha |
| Dilution: | WB 1:1,000-1:5,000; IC 1:100-1:1,000 |
| Purification Method: | Affinity purified |
| Concentration: | Lot dependent |
| Buffer: | PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
Background
This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.
Images
 | Western blotting analysis using anti-Retinoic acid receptor alpha antibody (Cat#62504). Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-Retinoic acid receptor alpha antibody (Cat#62504, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using FeQ™ ECL Substrate Kit (Cat#226). |
 | Western blotting analysis using anti-Retinoic Acid Receptor alpha antibody (Cat#62504). Retinoic Acid Receptor alpha expression in wild type (WT) and Retinoic Acid Receptor alpha shRNA knockdown (KD) HeLa cells with 20 μg of total cell lysates. Hsp90 α serves as a loading control. The blot was incubated with anti-Retinoic Acid Receptor alpha antibody (Cat#62504, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716). |
 | Immunocytochemical staining of HT-1080 cells with anti-Retinoic acid receptor alpha antibody (Cat#62504, 1:1,000). Nuclei were stained blue with DAPI; Retinoic acid receptor alpha was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm. |
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