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| Reactivity: | Human |
| Applications: | WB, FC, IC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal antibody |
| Gene Name: | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 |
| Gene Symbol: | SAMHD1 |
| Synonyms: | DCIP; CHBL2; HDDC1; MOP-5; SBBI88; hSAMHD1 |
| Gene ID: | 25939 |
| UniProt ID: | Q9Y3Z3 |
| Clone ID: | 24GB1010 |
| Immunogen: | A synthesized peptide derived from human SAMHD1 |
| Dilution: | WB 1:1,000-1:5,000; FC 1:2,000; IC 1:100-1:1,000 |
| Purification Method: | Affinity purified |
| Concentration: | Lot dependent |
| Buffer: | PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
Background
This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome.
Images
 | Western blotting analysis using anti-SAMHD1 antibody (Cat#62473). Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-SAMHD1 antibody (Cat#62473, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using FeQ™ ECL Substrate Kit (Cat#226). |
 | Western blotting analysis using anti-SAMHD1 antibody (Cat#62473). SAMHD1 expression in wild-type (WT) and SAMHD1 shRNA knockdown (KD) HeLa cells with 30 μg of total cell lysates . Hsp90 α serves as a loading control. The blot was incubated with anti-SAMHD1 antibody (Cat#62473, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716). |
 | Flow cytometric analysis of SAMHD1 expression in HeLa cells using SAMHD1 antibody (Cat#62473, 1:2,000). Green, isotype control; red, SAMHD1. |
 | Immunocytochemical staining of Hela cells with anti-SAMHD1 antibody (Cat#62473, 1:1,000). Nuclei were stained blue with DAPI; SAMHD1 was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: High. Scale bar: 20 μm. |
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