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| Reactivity: | Human, Mouse, Rat |
| Applications: | WB, FC, IC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal antibody |
| Gene Name: | transcription factor 7 like 2 |
| Gene Symbol: | TCF7L2 |
| Synonyms: | TCF4; TCF-4 |
| Gene ID: | 6934 |
| UniProt ID: | Q9NQB0 |
| Clone ID: | 25GB3275 |
| Immunogen: | A synthesized peptide derived from human TCF7L2 |
| Dilution: | WB 1:4,000-1:20,000; FC 1:2,000; IC 1:100-1:1,000 |
| Purification Method: | Affinity purified |
| Concentration: | Lot dependent |
| Buffer: | PBS with 0.09% Sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
Background
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.
Images
 | Western blotting analysis using anti-transcription factor 7 like 2 antibody (Cat#61671). Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-transcription factor 7 like 2 antibody (Cat#61671, 1:20,000) and HRP-conjugated goat anti rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716). |
 | Western blotting analysis using anti-transcription factor 7 like 2 antibody (Cat#61671). Transcription factor 7 like 2 expression in wild-type (WT) and transcription factor 7 like 2 (TCF7L2) knockdown (KD) HeLa cells with 20 μg of total cell lysates. Hsp90 α serves as a loading control. The blot was incubated with anti-transcription factor 7 like 2 antibody (Cat#61671, 1:2,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716). |
 | Flow cytometric analysis of Transcription factor 7 like 2 expression in HepG2 cells using anti-Transcription factor 7 like 2 antibody (Cat#61671, 1:2,000). Green, isotype control; red, Transcription factor 7 like 2. |
 | Immunocytochemical staining of HepG2 cells with anti-Transcription factor 7 like 2 antibody (Cat#61671, 1:1,000). Nuclei were stained blue with DAPI; Transcription factor 7 like 2 was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm. |
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