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| Reactivity: | Human |
| Applications: | WB, FC, IC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal antibody |
| Gene Name: | stimulator of interferon response cGAMP interactor 1 |
| Gene Symbol: | STING1 |
| Synonyms: | ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING; TMEM173; STING-beta |
| Gene ID: | 340061 |
| UniProt ID: | Q86WV6 |
| Clone ID: | 24GB5890 |
| Immunogen: | A synthesized peptide derived from human TMEM173 |
| Dilution: | WB 1:1,000-1:5,000; FC 1:2,000; IC 1:100-1:1,000 |
| Purification Method: | Affinity purified |
| Concentration: | Lot dependent |
| Buffer: | PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
Background
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.
Images
 | Western blotting analysis using anti-TMEM173 antibody (Cat#61113). Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-TMEM173 antibody (Cat#61113, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716). |
 | Western blotting analysis using anti-TMEM173 antibody (Cat#61113). TMEM173 expression in wild type (WT) and STING1 shRNA knockdown (KD) HeLa cells with 20 μg of total cell lysates. Hsp90 α serves as a loading control. The blot was incubated with anti-TMEM173 antibody (Cat#61113, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using Plus ECL Super Kit (Cat#636). STING1, Stimulator Of Interferon Response CGAMP Interactor 1. |
 | Flow cytometric analysis of TMEM173 expression in HT-1080 cells using TMEM173 antibody (Cat#61113, 1:2,000). Green, isotype control; red, TMEM173. |
 | Immunocytochemical staining of HT-1080 cells with TMEM173 antibody (Cat#61113, 1:1,000). Nuclei were stained blue with DAPI; TMEM173 was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm. |
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