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| Reactivity: | Human |
| Applications: | WB, FC |
| Host Species: | Mouse |
| Isotype: | IgG2b |
| Clonality: | Monoclonal antibody |
| Gene Name: | chromobox 8 |
| Gene Symbol: | CBX8 |
| Synonyms: | PC3; RC1 |
| Gene ID: | 57332 |
| UniProt ID: | Q9HC52 |
| Clone ID: | 24GB7980 |
| Immunogen: | Recombinant protein of human CBX8 |
| Dilution: | WB 1:200-1:1,000; FC 1:1,000 |
| Purification Method: | Affinity purified |
| Concentration: | Lot dependent |
| Buffer: | PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
Background
Enables methylated histone binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in chromatin and nucleoplasm. Part of PRC1 complex. Biomarker of esophagus squamous cell carcinoma and glioblastoma.
Images
 | Western blotting analysis using anti-chromobox 8 antibody (Cat#63809). Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-chromobox 8 antibody (Cat#63809, 1:1,000) and HRP-conjugated goat anti-mouse secondary antibody (Cat#101, 1:20,000) respectively. Image was developed using FeQ™ ECL Substrate Kit (Cat#226). |
 | Western blotting analysis using anti-chromobox 8 antibody (Cat#63809). Chromobox 8 expression in wild-type (WT) and chromobox 8 (CBX8) shRNA knockdown (KD) HeLa cells with 20 μg of total cell lysates. Hsp90 α serves as a loading control. The blot was incubated with anti-chromobox 8 antibody (Cat#63809, 1:1,000) and HRP-conjugated goat anti-mouse secondary antibody (Cat#101, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716). |
 | Flow cytometric analysis of Chromobox 8 expression in HeLa cells using anti-Chromobox 8 antibody (Cat#63809, 1:1,000). Green, isotype control; red, Chromobox 8. |
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