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| Reactivity: | Human |
| Applications: | WB, FC, IC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal antibody |
| Gene Name: | interleukin 13 receptor subunit alpha 1 |
| Gene Symbol: | IL13RA1 |
| Synonyms: | NR4; CT19; CD213A1; IL-13Ra |
| Gene ID: | 3597 |
| UniProt ID: | P78552 |
| Clone ID: | 23GB6655 |
| Immunogen: | A synthesized peptide derived from human IL13 receptor alpha 1 |
| Dilution: | WB 1:1,000-1:5,000; FC 1:2,000; IC 1:100-1:1,000 |
| Purification Method: | Affinity purified |
| Concentration: | Lot dependent |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
Background
The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.
Images
 | Western blotting analysis using anti-IL13 receptor alpha 1 antibody (Cat#62240). Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-IL13 receptor alpha 1 antibody (Cat#62240, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using FeQ™ ECL Substrate Kit (Cat#226). |
 | Western blotting analysis using anti-IL13 receptor α 1 antibody (Cat#62240). IL13 receptor α 1 expression in wild type (WT) and IL13 receptor α 1 shRNA knockdown (KD) HeLa cells with 20 μg of total cell lysates. Hsp90 α serves as a loading control. The blot was incubated with anti-IL13 receptor α 1 antibody (Cat#62240, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716). |
 | Flow cytometric analysis of IL13 receptor alpha 1 expression in HepG2 cells using IL13 receptor alpha 1 antibody (Cat#62240, 1:2,000). Green, isotype control; red, IL13 receptor alpha 1. |
 | Immunocytochemical staining of Hela cells with anti-IL13 receptor alpha 1 antibody (Cat#62240, 1:1,000). Nuclei were stained blue with DAPI; IL13 receptor alpha 1 was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm. |
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