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| Reactivity: | Human, Rat |
| Applications: | WB |
| Host Species: | Mouse |
| Isotype: | IgG2b |
| Clonality: | Monoclonal antibody |
| Gene Name: | leukotriene A4 hydrolase |
| Gene Symbol: | LTA4H |
| Synonyms: | LTA4; Leukotriene A-4 hydrolase; LTA-4 hydrolase; Leukotriene A(4) hydrolase |
| Gene ID: | 4048 |
| UniProt ID: | P09960 |
| Clone ID: | 24GB5535 |
| Immunogen: | Recombinant protein of human LTA4H |
| Dilution: | WB 1:2,500-1:5,000 |
| Purification Method: | Affinity purified |
| Concentration: | Lot dependent |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
Background
The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene.
Images
 | Western blotting analysis using anti-leukotriene A4 hydrolase antibody (Cat#63418). Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-leukotriene A4 hydrolase antibody (Cat#63418, 1:5,000) and HRP-conjugated goat anti-mouse secondary antibody (Cat#101, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit(Cat#716). |
 | Western blotting analysis using anti-leukotriene A4 hydrolase antibody (Cat#63418). Leukotriene A4 hydrolase expression in wild type (WT) and leukotriene A4 hydrolase (LTA4H) shRNA knockdown (KD) HeLa cells with 20 μg of total cell lysates. Hsp90 α serves as a loading control. The blot was incubated with anti-leukotriene A4 hydrolase antibody (Cat#63418, 1:5,000) and HRP-conjugated goat anti-mouse secondary antibody (Cat#101, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716). |
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