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| Reactivity: | Human, Rat |
| Applications: | WB |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | Parkinsonism associated deglycase |
| Gene Symbol: | PARK7 |
| Synonyms: | DJ1; DJ-1; GATD2; HEL-S-67p |
| Gene ID: | 11315 |
| UniProt ID: | Q99497 |
| Immunogen: | A synthesized peptide derived from human DJ-1 |
| Dilution: | WB 1:200-1:1,000 |
| Purification Method: | Affinity purified |
| Concentration: | Lot dependent |
| Buffer: | PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
Background
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene.
Images
 | Western blotting analysis using anti-PARK7 antibody (Cat#64982). Total cell lysates (10 μg for H9c2, and 30 μg for others) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-PARK7 antibody (Cat#64982, 1:1,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716). |
 | Western blotting analysis using anti-PARK7 antibody (Cat#64982). PARK7 expression in wild-type (WT) and PARK7 shRNA knockdown (KD) HeLa cells with 20 μg of total cell lysates. Hsp90 α serves as a loading control. The blot was incubated with anti-PARK7 antibody (Cat#64982, 1:1,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using FeQ™ ECL Substrate Kit (Cat#226). |
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