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| Reactivity: | Human, Mouse |
| Applications: | WB, FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal antibody |
| Gene Name: | N-myc downstream regulated 1 |
| Gene Symbol: | NDRG1 |
| Synonyms: | GC4; RTP; DRG1; NDR1; NMSL; TDD5; CAP43; CMT4D; DRG-1; HMSNL; RIT42; TARG1; PROXY1 |
| Gene ID: | 10397 |
| UniProt ID: | Q92597 |
| Clone ID: | 24GB4985 |
| Immunogen: | A synthesized peptide derived from human Phospho-NDRG1 (Ser330) |
| Dilution: | WB 1:1,000-1:5,000; FC 1:2,000 |
| Purification Method: | Affinity purified |
| Concentration: | Lot dependent |
| Buffer: | PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
Background
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Images
 | Western blotting analysis using anti-phospho-NDRG1 (Ser330) antibody (Cat#63306). Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-phospho-NDRG1 (Ser330) antibody (Cat#63306, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716). |
 | Western blotting analysis using anti-phospho-NDRG1 (Ser330) antibody (Cat#63306). Phospho-NDRG1 (Ser330) expression in wild-type (WT) and NDRG1 shRNA knockdown (KD) HeLa cells with 20 μg of total cell lysates. Hsp90 α serves as a loading control. The blot was incubated with anti-phospho-NDRG1 (Ser330) antibody (Cat#63306, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716). NDRG1, N-myc downstream regulated 1. |
 | Flow cytometric analysis of phospho-NDRG1 (Ser330) expression in HepG2 cells using anti-phospho-NDRG1 (Ser330) antibody (Cat#63306, 1:2,000). Green, isotype control; red, phospho-NDRG1 (Ser330). |
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