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| Reactivity: | Human, Mouse, Rat |
| Applications: | WB, FC, IC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal antibody |
| Gene Name: | somatostatin receptor 5 |
| Gene Symbol: | SSTR5 |
| Synonyms: | SST5; SS-5-R |
| Gene ID: | 6755 |
| UniProt ID: | P35346 |
| Clone ID: | 24GB2600 |
| Immunogen: | A synthesized peptide derived from human SSTR5 |
| Dilution: | WB 1:1,000-1:5,000; FC 1:2,000; IC 1:100-1:1,000 |
| Purification Method: | Affinity purified |
| Concentration: | Lot dependent |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
Background
Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.
Images
 | Western blotting analysis using anti-somatostatin receptor 5 antibody (Cat#62679). Total cell lysates (5 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-somatostatin receptor 5 antibody (Cat#62679, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using FeQ™ ECL Substrate Kit (Cat#226). |
 | Western blotting analysis using anti-Somatostatin receptor 5 antibody (Cat#62679). Somatostatin receptor 5 expression in wild type (WT) and Somatostatin receptor 5 shRNA knockdown (KD) HeLa cells with 20 μg of total cell lysates . β-Tubulin serves as a loading control. The blot was incubated with anti-Somatostatin receptor 5 antibody (Cat#62679, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716). |
 | Flow cytometric analysis of Somatostatin receptor 5 expression in HepG2 cells using anti-Somatostatin receptor 5 antibody (Cat#62679, 1:2,000). Green, isotype control; red, Somatostatin receptor 5. |
 | Immunocytochemical staining of HepG2 cells with anti-Somatostatin receptor 5 antibody (Cat#62679, 1:1,000). Nuclei were stained blue with DAPI; Somatostatin receptor 5 was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: High. Scale bar: 20 μm. |
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