Your shopping cart is empty!
| Reactivity: | Human, Mouse, Rat |
| Applications: | WB, FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal antibody |
| Gene Name: | transmembrane protein 43 |
| Gene Symbol: | TMEM43 |
| Synonyms: | LUMA; ARVC5; ARVD5; AUNA3; EDMD7; EDMD7; AUNA2 |
| Gene ID: | 79188 |
| UniProt ID: | Q9BTV4 |
| Clone ID: | 24GB2325 |
| Immunogen: | A synthesized peptide derived from human TMEM43 |
| Dilution: | WB 1:1,000-1:5,000; FC 1:2,000 |
| Purification Method: | Affinity purified |
| Concentration: | Lot dependent |
| Buffer: | PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
Background
This gene belongs to the TMEM43 family. Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. This gene contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC.
Images
 | Western blotting analysis using anti-transmembrane protein 43 antibody (Cat#62719). Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-transmembrane protein 43 antibody (Cat#62719, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using FeQ™ ECL Substrate Kit (Cat#226). |
 | Western blotting analysis using anti-Transmembrane protein 43 antibody (Cat#62719). Transmembrane protein 43 expression in wild type (WT) and Transmembrane protein 43 shRNA knockdown (KD) HeLa cells with 20 μg of total cell lysates. β-Tubulin serves as a loading control. The blot was incubated with anti-Transmembrane protein 43 antibody (Cat#62719, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716). |
 | Flow cytometric analysis of Transmembrane protein 43 expression in C2C12 cells using anti-Transmembrane protein 43 antibody (Cat#62719, 1:2,000). Green, isotype control; red, Transmembrane protein 43. |
You may also be interested in:
