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| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | KDS rabbit polyclonal antibody |
Gene Name: | Serine/threonine-protein kinase TAO3 |
Synonyms: | CTCL-associated antigen HD-CL-09, hKFC-A, Dendritic cell-derived protein kinase, DPK, JNK/SAPK-inhibitory kinase, JIK, KDS, Jun kinase-inhibitory kinase, TAOK3, MAP3K18 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human KDS |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Cytoplasm |
Uniprot ID: | Q9H2K8 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human | 1: 500-1: 1000 | breast cancer, colon cancer |
Background
TAOK3 (Serine/threonine-protein kinase TAO3) is also named as DPK, JIK, KDS, MAP3K18 and belongs to the STE Ser/Thr protein kinase family. It acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, it is involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. And this protein can be autophosphorylated.
Images
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Immunohistochemistry of paraffin embedded human breast cancer using TAOK3 (GB111288) at dilution of 1:550 (400x lens) |
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Immunohistochemistry of paraffin embedded human colon cancer using TAOK3 (GB111288) at dilution of 1:550 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |