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KO-Validated Ythdc1 Rabbit mAb (20 μl)
| Reactivity: | Human |
| Applications: | WB, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal antibody |
| Gene Name: | YTH domain containing 1 |
| Gene Symbol: | Ythdc1 |
| Synonyms: | mKIAA1966; A730098D12Rik; Mouse Ythdc1 |
| Gene ID: | 231386 |
| UniProt ID: | E9Q5K9 |
| Clone ID: | 3K8D1 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 597-736 of mouse Ythdc1 (NP_808348.2). |
| Purification Method: | Affinity purification |
| Dilution: | WB 1:1000-1:2000 |
| Concentration: | 1.39 mg/ml |
| Buffer: | PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-Ythdc1 monoclonal antibody |
Background
Predicted to enable N6-methyladenosine-containing RNA binding activity and mRNA binding activity. Involved in posttranscriptional regulation of gene expression. Acts upstream of or within gamete generation; in utero embryonic development; and regulation of mRNA processing. Located in nucleus. Orthologous to human YTHDC1 (YTH domain containing 1).
Images
 | Western blot analysis of lysates from Ythdc1-cKO mouse ES cells, using [KO Validated] Ythdc1 Rabbit mAb (A25682) at 1:1000 dilution incubated overnight at 4℃. Ythdc1-cKO mouse ES cells were treated by 4OHT. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 45s. |
 | Western blot analysis of lysates from HeLa cells using [KO Validated] Ythdc1 Rabbit mAb (A25682) at 1:1000 dilution incubated overnight at 4℃. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 45s. |
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