Lentivirus CBX3 (5×200 μl)

Lentivirus CBX3 (5×200 μl)

Cat. #: M2419
Availability: In Stock
$699.00
-+
Product Category: Human lentivirus expressing CBX3    
Description: Premade lentivirus for over-expression of human CBX3 and control, ready to use format.
Gene Name: chromobox 3
Gene Symbol: CBX3
Synonyms: HECH; HP1gamma; HP1-GAMMA; HP1Hs-gamma
Gene ID: 11335
Vector: PDS407_pL-CMV-RFP-ccdB-puro
Promoter: CMV
Titer: ≥1E+8TU/ml
Buffer: PBS
Storage: -80°C
Documents: Manual-Ready-to-Use Recombinant Lentivirus



Background

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.



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