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| Product Category: | Human lentivirus expressing CD86 |
| Description: | Premade lentivirus for over-expression of human CD86 and control, ready to use format. |
| Gene Name: | CD86 molecule |
| Gene Symbol: | CD86 |
| Synonyms: | B70; B7-2; B7.2; LAB72; CD28LG2 |
| ACCN: | NM_001206924.2 |
| Gene ID: | 942 |
| Vector: | VP038-CMV-MCS-EF1-Hygr |
| Promoter: | CMV |
| Selection Antibiotic: | Hygromycin |
| Titer: | ≥1E+8TU/ml |
| Buffer: | PBS |
| Storage: | -80°C |
| Documents: | Manual-Ready-to-Use Recombinant Lentivirus |
Background
The gene CD86 encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.
Optional Services
| Name | Catalog # | Turnaround Time | View |
| Gene Synthesis | S0012 | Quote |  |
| Lentivirus Packaging | S0032 | Quote | |
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