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| Product Category: | Mouse lentivirus expressing Cxcr4 |
| Description: | Premade lentivirus for over-expression of mouse Cxcr4 and control, ready to use format. |
| Gene Name: | C-X-C motif chemokine receptor 4 |
| Gene Symbol: | Cxcr4 |
| Synonyms: | CD184; LESTR; Sdf1r; CXC-R4; CXCR-4; Cmkar4; PB-CKR; b2b220Clo; PBSF/SDF-1 |
| ACCN: | NM_001356509.1 |
| Gene ID: | 12767 |
| Vector: | VP001-CMV-MCS-EF1-ZsGreen-T2A-PURO |
| Promoter: | CMV |
| Selection Antibiotic: | Puromycin |
| Titer: | ≥1E+8TU/ml |
| Buffer: | PBS |
| Storage: | -80°C |
| Documents: | Manual-Ready-to-Use Recombinant Lentivirus |
Background
Predicted to enable several functions, including chemokine receptor activity; cytoskeletal protein binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including nervous system development; positive regulation of cold-induced thermogenesis; and positive regulation of oligodendrocyte differentiation. Acts upstream of or within several processes, including CXCL12-activated CXCR4 signaling pathway; circulatory system development; and nervous system development. Located in cell-cell junction; external side of plasma membrane; and growth cone. Is expressed in several structures, including alimentary system; cardiovascular system; embryo mesenchyme; extraembryonic component; and nervous system. Used to study WHIM syndrome 1; cardiomyopathy; and congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including WHIM syndrome 1; bone disease (multiple); hematologic cancer (multiple); pancreatic adenocarcinoma; and prostate cancer. Orthologous to human CXCR4 (C-X-C motif chemokine receptor 4).
Optional Services
| Name | Catalog # | Turnaround Time | View |
| Gene Synthesis | S0012 | Quote |  |
| Lentivirus Packaging | S0032 | Quote | |
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