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| Product Category: | Human lentivirus expressing FAM111B |
| Description: | Premade lentivirus for over-expression of human FAM111B and control, ready to use format. |
| Gene Name: | FAM111 trypsin like peptidase B |
| Gene Symbol: | FAM111B |
| Synonyms: | CANP; POIKTMP |
| ACCN: | NM_198947.4 |
| Gene ID: | 374393 |
| Vector: | PDS279_pL-CMV-GFP-ccdB-puro |
| Fusion Tag: | 3×Flag |
| Promoter: | CMV |
| Selection Antibiotic: | Puromycin |
| Titer: | ≥1E+8TU/ml |
| Buffer: | PBS |
| Storage: | -80°C |
| Documents: | Manual-Ready-to-Use Recombinant Lentivirus |
Background
This gene encodes a protein with a trypsin-like cysteine/serine peptidase domain in the C-terminus. Mutations in this gene are associated with an autosomal dominant form of hereditary fibrosing poikiloderma (HFP). Affected individuals display mottled pigmentation, telangiectasia, epidermal atrophy, tendon contractures, and progressive pulmonary fibrosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A paralog of this gene which also has a trypsin‐like peptidase domain, FAM111A, is located only 16 kb from this gene on human chromosome 11q12.1.
Optional Services
| Name | Catalog # | Turnaround Time | View |
| Gene Synthesis | S0012 | Quote |  |
| Lentivirus Packaging | S0032 | Quote | |
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