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| Product Category: | Human lentivirus expressing LIN28A |
| Description: | Premade lentivirus for over-expression of human LIN28A and control, ready to use format. |
| Gene Name: | lin-28 homolog A |
| Gene Symbol: | LIN28A |
| Synonyms: | CSDD1; LIN28; LIN-28; ZCCHC1; lin-28A |
| ACCN: | NM_024674.6 |
| Gene ID: | 79727 |
| Vector: | VP039-CMV-MCS-EF1-mcherry-t2a-Neo |
| Promoter: | CMV |
| Selection Antibiotic: | Puromycin |
| Titer: | ≥1E+8TU/ml |
| Buffer: | PBS |
| Storage: | -80°C |
| Documents: | Manual-Ready-to-Use Recombinant Lentivirus |
Background
This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues.
Optional Services
| Name | Catalog # | Turnaround Time | View |
| Gene Synthesis | S0012 | Quote |  |
| Lentivirus Packaging | S0032 | Quote | |
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