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| Product Category: | Human lentivirus expressing LIN28B |
| Description: | Premade lentivirus for over-expression of human LIN28B and control, ready to use format. |
| Gene Name: | lin-28 homolog B |
| Gene Symbol: | LIN28B |
| Synonyms: | CSDD2 |
| ACCN: | NM_001004317.4 |
| Gene ID: | 389421 |
| Vector: | VP039-CMV-MCS-EF1-mcherry-t2a-Neo |
| Promoter: | CMV |
| Selection Antibiotic: | Puromycin |
| Titer: | ≥1E+8TU/ml |
| Buffer: | PBS |
| Storage: | -80°C |
| Documents: | Manual-Ready-to-Use Recombinant Lentivirus |
Background
The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation.
Optional Services
| Name | Catalog # | Turnaround Time | View |
| Gene Synthesis | S0012 | Quote |  |
| Lentivirus Packaging | S0032 | Quote | |
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