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| Product Category: | Mouse lentivirus expressing Nlrp3 |
| Description: | Premade lentivirus for over-expression of mouse Nlrp3 and control, ready to use format. |
| Gene Name: | NLR family, pyrin domain containing 3 |
| Gene Symbol: | Nlrp3 |
| Synonyms: | FCU; MWS; FCAS; Cias1; Mmig1; NALP3; Pypaf1; AII/AVP; AGTAVPRL |
| ACCN: | NM_145827.4 |
| Gene ID: | 216799 |
| Vector: | VP001-CMV-MCS-3×Flag-EF1-ZsGreen-T2A-PURO |
| Fusion Tag: | 3×Flag |
| Promoter: | CMV |
| Selection Antibiotic: | Puromycin |
| Titer: | ≥1E+8TU/ml |
| Buffer: | PBS |
| Storage: | -80°C |
| Documents: | Manual-Ready-to-Use Recombinant Lentivirus |
Background
Enables several functions, including ATP hydrolysis activity; phosphatidylinositol-4-phosphate binding activity; and signaling adaptor activity. Involved in several processes, including positive regulation of immune response; positive regulation of macromolecule biosynthetic process; and response to bacterium. Acts upstream of or within several processes, including acute inflammatory response; defense response to virus; and positive regulation of cysteine-type endopeptidase activity. Located in interphase microtubule organizing center; mitochondrion; and nucleus. Part of NLRP3 inflammasome complex. Is active in membrane. Is expressed in central nervous system and retina. Used to study CINCA Syndrome; familial cold autoinflammatory syndrome 1; and metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3).
Optional Services
| Name | Catalog # | Turnaround Time | View |
| Gene Synthesis | S0012 | Quote |  |
| Lentivirus Packaging | S0032 | Quote | |
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