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| Product Category: | Human lentivirus expressing SIRT1 |
| Description: | Premade lentivirus for over-expression of human SIRT1 and control, ready to use format. |
| Gene Name: | sirtuin 1 |
| Gene Symbol: | SIRT1 |
| Synonyms: | SIR2; SIR2L1; SIR2alpha |
| ACCN: | NM_001142498.2, NM_001314049.2, NM_012238.5 |
| Gene ID: | 23411 |
| Vector: | pLKO-CMV-MCS-EF1-puro |
| Promoter: | CMV |
| Selection Antibiotic: | Puromycin |
| Titer: | ≥1E+8TU/ml |
| Buffer: | PBS |
| Storage: | -80°C |
| Documents: | Manual-Ready-to-Use Recombinant Lentivirus |
Background
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
Optional Services
| Name | Catalog # | Turnaround Time | View |
| Gene Synthesis | S0012 | Quote |  |
| Lentivirus Packaging | S0032 | Quote | |
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