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| Reactivity: | Human |
| Applications: | WB, IF/IC, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | mitotic arrest deficient 1 like 1 |
| Gene Symbol: | MAD1L1 |
| Synonyms: | MAD1; MVA7; PIG9; TP53I9; TXBP181; MAD1/MAD1L1 |
| Gene ID: | 8379 |
| UniProt ID: | Q9Y6D9 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 360-700 of human MAD1/MAD1/MAD1L1 (NP_001013859.1). |
| Dilution: | WB 1:500-1:2000; IF/IC 1:50-1:200 |
| Purification Method: | Affinity purification |
| Concentration: | 1.1 mg/ml |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
| Documents: | Manual-MAD1L1 antibody |
Background
MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants.
Images
 | Western blot analysis of various lysates using MAD1/MAD1L1 Rabbit pAb (A1153) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). |
 | Immunofluorescence analysis of U2OS cells using MAD1/MAD1L1 Rabbit pAb (A1153).Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (AS007) at 1:500 dilution. |
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