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| Reactivity: | M,R & M |
| Applications: | IHC/IF & ICC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Neudesin |
Synonyms: | CIR2, NEUDESIN, Neudesin/NENF, SCIRP10, SPUF, SPUF protein |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse NENF |
Uniprot ID: | Q9CQ45 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Secreted |
Product Usage Information
IHC/IF | Mouse, Rat | 1: 800-1: 2400 | spleen, liver, testis |
ICC/IF | Mouse | 1: 100-1: 400 | NIH-3T3 |
Background
Acts as a neurotrophic factor in postnatal mature neurons, enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocytes. Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme. Acts also as an anorexigenic neurotrophic factor that contributes to energy balance.
Images
| Immunohistochemistry analysis of paraffin embedded rat spleen using NENF (GB114996) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin embedded rat liver using NENF (GB114996) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin embedded mouse testis using NENF (GB114996) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin embedded rat testis using NENF (GB114996) at dilution of 1: 800 |
| Immunocytochemistry analysis of 4% paraformaldehyde-fixed NIH-3T3 cells using NENF (GB114996) at dilution of 1: 200 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |