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Anti-NOTCH3 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | NOTCH3 rabbit polyclonal antibody |
Gene Name: | Neurogenic locus notch homolog protein 3 |
Synonyms: | Notch 3, CADASIL, CASIL, Notch homolog 3, Notch 3 intracellular domain, IMF2, LMNS |
Immunogen: | Recombinant protein corresponding to Mouse NOTCH3 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Nucleus |
Uniprot ID: | Q61982, Q9R172 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 500-1: 1500 | brain, cerebellum, lung, placenta, skin |
Background
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined.
Images
| Immunohistochemistry of paraffin embedded mouse brain using notch3 (GB112035) at dilution of 1:700 (200x lens) |
| Immunohistochemistry of paraffin embedded mouse lung using notch3 (GB112035) at dilution of 1:700 (250x lens) |
| Immunohistochemistry of paraffin embedded rat brain using notch3 (GB112035) at dilution of 1:700 (200x lens) |
| Immunohistochemistry of paraffin embedded rat placenta using notch3 (GB112035) at dilution of 1:700 (250x lens) |
| Immunofluorescence of paraffin embedded mouse cerebellum using notch3 (GB112035) at dilution of 1:650 (250x lens) |
| Immunofluorescence of paraffin embedded mouse skin using notch3 (GB112035) at dilution of 1:650 (400x lens) |
| Immunofluorescence of paraffin embedded rat lung using notch3 (GB112035) at dilution of 1:650 (350x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |