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| Reactivity: | Mouse, Rat |
| Applications: | WB, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | nuclear receptor subfamily 1 group H member 4 |
| Gene Symbol: | NR1H4 |
| Synonyms: | BAR; FXR; HRR1; HRR-1; PFIC5; RIP14; NR1H4 |
| Gene ID: | 9971 |
| UniProt ID: | Q96RI1 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human NR1H4 (NP_001193922.1). |
| Dilution: | WB 1:500-1:2000 |
| Purification Method: | Affinity purification |
| Concentration: | 2.26 mg/ml |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
| Documents: | Manual-NR1H4 antibody |
Background
This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members. This protein functions as a receptor for bile acids, and when bound to bile acids, binds to DNA and regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described.
Images
 | Western blot analysis of lysates from Rat liver, using NR1H4 Rabbit pAb (A12788) at 1:2000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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