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| Reactivity: | Human, Rat |
| Applications: | IF/IC, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | phosphodiesterase 4C |
| Gene Symbol: | PDE4C |
| Synonyms: | DPDE1; PDE21; PDE4C |
| Gene ID: | 5143 |
| UniProt ID: | Q08493 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 638-712 of human PDE4C (NP_000914.2). |
| Dilution: | IF/IC 1:100-1:500 |
| Purification Method: | Affinity purification |
| Concentration: | 1.61 mg/ml |
| Buffer: | PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
| Documents: | Manual-PDE4C antibody |
Background
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Images
 | Immunofluorescence analysis of PC-12 cells using PDE4C Rabbit pAb (A13038) at dilution of 1:400 (40x lens).Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (AS007) at 1:500 dilution. Blue: DAPI for nuclear staining. |
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