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PE/Cyanine7 Rabbit anti-Human CD45RA mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | PE-Cy7. Ex:565nm. Em:778nm. |
| Gene Name: | protein tyrosine phosphatase receptor type C |
| Gene Symbol: | PTPRC |
| Synonyms: | LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180; IMD105 |
| Gene ID: | 5788 |
| UniProt ID: | P08575-8 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-482 of human CD45RA (P08575-8). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.01 mg/ml |
| Buffer: | PBS with 0.09% Sodium azide,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-PTPRC Antibody |
Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
Images
 | Flow cytometry: 1×10^6 Jurkat cells were surface-stained with PE/Cyanine7 Rabbit IgG isotype control (5 μl/Test,left) or PE/Cyanine7 Rabbit anti-Human CD45RA mAb (A26566,5 μl/Test,right). |
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