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PE/Cyanine7 Rabbit anti-Human/Monkey CD25 mAb (100 T)
| Reactivity: | Human, Monkey |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | PE-Cy7. Ex:565nm. Em:778nm. |
| Gene Name: | interleukin 2 receptor subunit alpha |
| Gene Symbol: | IL2RA |
| Synonyms: | p55; CD25; IL2R; IMD41; TCGFR; IDDM10 |
| Gene ID: | 3559 |
| UniProt ID: | P01589 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-213 of human CD25 (NP_000408.1). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/ml |
| Buffer: | PBS with 0.09% Sodium azide,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-IL2RA Antibody |
Background
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk.
Images
 | Flow cytometry: 1×10^6 Human PBMC were surface-stained with PE/Cyanine7 Rabbit IgG isotype control (5 μl/Test,left) or PE/Cyanine7 Rabbit anti-Human/Monkey CD25 mAb (A27400,5 μl/Test,right). Cells in the Lymphocyte gate were used for analysis. |
 | Flow cytometry: 1×10^6 Monkey PBMC were surface-stained with PE/Cyanine7 Rabbit IgG isotype control (5 μl/Test,left) or PE/Cyanine7 Rabbit anti-Human/Monkey CD25 mAb (A27400,5 μl/Test,right). Cells in the Lymphocyte gate were used for analysis. |
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