Your shopping cart is empty!
PE Rabbit anti-Human CD124/IL-4Rα mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | PE. Ex:565nm. Em:574nm. |
| Gene Name: | interleukin 4 receptor |
| Gene Symbol: | IL4R |
| Synonyms: | CD124; IL4RA; IL-4RA |
| Gene ID: | 3566 |
| UniProt ID: | P24394 |
| Clone ID: | 4O7L9 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-232 of human CD124/IL-4Rα (NP_000409.1). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-IL4R Antibody |
Background
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
Images
 | Flow cytometry: 1×10^6 MOLT-4 cells (negative control,left) and Daudi cells (right) were surface-stained with PE Rabbit anti-Human CD124/IL-4Rα mAb (A25725,5 μl/Test,orange line) or PE Rabbit IgG isotype control (A24172,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 Daudi cells were surface-stained with PE Rabbit IgG isotype control (A24172,5 μl/Test,left) or PE Rabbit anti-Human CD124/IL-4Rα mAb (A25725,5 μl/Test,right). |
You may also be interested in:
