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PE Rabbit anti-Human CD170/Siglec-5 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | PE. Ex:565nm. Em:574nm. |
| Gene Name: | sialic acid binding Ig like lectin 5 |
| Gene Symbol: | SIGLEC5 |
| Synonyms: | CD170; OBBP2; CD33L2; OB-BP2; SIGLEC-5 |
| Gene ID: | 8778 |
| UniProt ID: | O15389 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 17-434 of human CD170/Siglec-5 (NP_003821.1). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/ml |
| Buffer: | PBS with 0.09% Sodium azide,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-SIGLEC5 Antibody |
Background
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.
Images
 | Flow cytometry: 1×10^6 K-562 cells (negative control,left) and U-937 cells (right) were surface-stained with PE Rabbit anti-Human CD170/Siglec-5 mAb (A26119,5 μl/Test,orange line) or PE Rabbit IgG isotype control (A24172,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 U-937 cells were surface-stained with PE Rabbit IgG isotype control (A24172,5 μl/Test,left) or PE Rabbit anti-Human CD170/Siglec-5 mAb (A26119,5 μl/Test,right). |
 | Flow cytometry: 1×10^6 Human PBMC were surface-stained with PE Rabbit anti-Human CD170/Siglec-5 mAb (A26119,5 μl/Test,orange line) or PE Rabbit IgG isotype control (A24172,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
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