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| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | PE. Ex:565nm. Em:574nm. |
| Gene Name: | integrin subunit beta 2 |
| Gene Symbol: | ITGB2 |
| Synonyms: | LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1 |
| Gene ID: | 3689 |
| UniProt ID: | P05107 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-769 of human CD18 (NP_000202.3). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.02 mg/ml |
| Buffer: | PBS with 0.09% Sodium azide,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-ITGB2 Antibody |
Background
This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants.
Images
 | Flow cytometry: 1×10^6 HeLa cells (negative control,left) and THP-1 cells (right) were surface-stained with PE Rabbit anti-Human CD18 mAb (A27214,5 μl/Test,orange line) or PE Rabbit IgG isotype control (A24172,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 Human PBMC were surface-stained with PE Rabbit IgG isotype control (A24172,5 μl/Test,left) or PE Rabbit anti-Human CD18 mAb (A27214,5 μl/Test,right). |
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