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| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | PE. Ex:565nm. Em:574nm. |
| Gene Name: | TNF receptor superfamily member 8 |
| Gene Symbol: | TNFRSF8 |
| Synonyms: | CD30; Ki-1; D1S166E |
| Gene ID: | 943 |
| UniProt ID: | P28908 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-379 of human CD30 (NP_001234.3). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/ml |
| Buffer: | PBS with 0.09% Sodium azide,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-TNFRSF8 Antibody |
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Images
 | Flow cytometry: 1×10^6 A549 cells (negative control,left) and K-562 cells (right) were surface-stained with PE Rabbit anti-Human CD30 mAb (A26396,5 μl/Test,orange line) or PE Rabbit IgG isotype control (A24172,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 K-562 cells were surface-stained with PE Rabbit IgG isotype control (A24172,5 μl/Test,left) or PE Rabbit anti-Human CD30 mAb (A26396,5 μl/Test,right). |
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