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PE Rabbit anti-Human PD-1/CD279 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | PE. Ex:565nm. Em:574nm. |
| Gene Name: | programmed cell death 1 |
| Gene Symbol: | PDCD1 |
| Synonyms: | PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; AIMTBS |
| Gene ID: | 5133 |
| UniProt ID: | Q15116 |
| Clone ID: | 1M6Z9 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-168 of human PD-1/CD279 (NP_005009.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.02 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-PDCD1 Antibody |
Background
Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity.
Images
 | Flow cytometry: 1×10^6 293T cells (negative control,left) and MOLT-4 cells (right) were surface-stained with PE Rabbit anti-Human PD-1/CD279 mAb (A25730,5 μl/Test,orange line) or PE Rabbit IgG isotype control (A24172,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 MOLT-4 cells were surface-stained with PE Rabbit IgG isotype control (A24172,5 μl/Test,left) or PE Rabbit anti-Human PD-1/CD279 mAb (A25730,5 μl/Test,right). |
 | Flow cytometry: 1×10^6 Human PBMC (negative control,left) and Human PBMC (treated with PHA,right) were surface-stained with PE Rabbit anti-Human PD-1/CD279 mAb (A25730,5 μl/Test,orange line) or PE Rabbit IgG isotype control (A24172,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 Human PBMC (treated with PHA,right) were surface-stained with PE Rabbit IgG isotype control (A24172,5 μl/Test,left) or PE Rabbit anti-Human PD-1/CD279 mAb (A25730,5 μl/Test,right). |
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