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| Reactivity: | Human |
| Applications: | IF/IC, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | protein inhibitor of activated STAT 3 |
| Gene Symbol: | PIAS3 |
| Synonyms: | ZMIZ5; PIAS3 |
| Gene ID: | 10401 |
| UniProt ID: | Q9Y6X2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 399-628 of human PIAS3 (NP_006090.2). |
| Dilution: | IF/IC 1:50-1:200 |
| Purification Method: | Affinity purification |
| Concentration: | 5.41 mg/ml |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
| Documents: | Manual-PIAS3 antibody |
Background
This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined.
Images
 | Immunofluorescence analysis of U2OS cells using PIAS3 Rabbit pAb (A13394).Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (AS007) at 1:500 dilution. |
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