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| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | PYM rabbit polyclonal |
Gene Name: | Partner of Y14 and mago |
Synonyms: | PYM homolog 1 exon junction complex-associated factor, Protein wibg homolog, Pym1, Pym, Wibg |
Immunogen: | Recombinant protein corresponding to Mouse PYM |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
IHC/IF | Mouse | 1: 3000-1: 6000 | prefrontal lobe, heart |
Background
Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated.
Images
| Immunohistochemistry analysis of paraffin-embedded mouse prefrontal lobe using PYM (GB112784) at dilution of 1: 6000 |
| Immunohistochemistry analysis of paraffin-embedded mouse heart using PYM (GB112784) at dilution of 1: 6000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |