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Anti-Phospho-EGF Receptor (Y1172) Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Epidermal growth factor receptor |
Synonyms: | ADGRE1, Adhesion G protein-coupled receptor E1, EGF like module receptor 1, EMR1, EMR1 hormone receptor, EGF Receptor, P-EGFR |
Immunogen: | KLH conjugated Synthetic phosphopeptide corresponding to Human EGF Receptor (Tyr1172) |
Uniprot ID: | P00533 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 134 kDa / 175 kDa |
Product Usage Information
WB | Human | 1: 300-1: 600 | HeLa, A549, A-431 |
Background
EMR1 (EGF-like module containing mucin-like hormone receptor 1), also known as Adhesion G protein-coupled receptor E1 (ADGRE1), is a surface receptor with seven transmembrane segments that belongs to the EGF-7-transmembrane family of G protein-coupled receptors (PMID: 14647991, 7601460). EMR1 expression is restricted to eosinophilic granulocytes, where expression is overlapping with the eotaxin receptor CCR3 and the immunoglobulin-like lectin Siglec-8. Absence on other leukocytes, including basophils, implies that EMR1 is a highly specific marker for eosinophils in humans and may be used as a novel therapeutic target for eosinophilic disorders.
Images
| Western blot analysis of P-EGFR (GB114199) at dilution of 1: 1000 The figure above was treated with phospho-blocking pepide, the figure below was treated with non-phospho- blocking pepide |
| Western blot analysis of P-EGFR (GB114199) at dilution of 1: 1000 The figure above was treated with lambda phosphatase, the figure below was untreated |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |