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Product Category:
Human Adenovirus Type5 (dE1/E3) expressing THAP1
Description:
This recombinant human adenovirus type 5 (dE1/E3) expresses THAP domain containing, apoptosis associated protein 1 (THAP1, also known as DYT6, FLJ10477, MGC33014) under CMV promoter.
Gene Name:
THAP domain containing, apoptosis associated protein 1
ACCN:
NM_018105, NP_060575
Gene ID:
55145
GI Number:
8922446
Fusion Tag:
V5 tag at C-terminal
Promoter:
CMV
Titer:
1×1010~1×1011 PFU/ml
Storage Buffer:
DMEM with 2.5% BSA, 2.5% glycerol
Background:
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
Storage:
-80°C
Documents:
