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| Product Category: | Human lentivirus expressing APC |
| Description: | Premade lentivirus for over-expression of human APC and control, ready to use format. |
| Gene Name: | APC regulator of WNT signaling pathway |
| Gene Symbol: | APC |
| Synonyms: | GS; DP2; DP3; BTPS2; DESMD; DP2.5; PPP1R46 |
| Gene ID: | 324 |
| Vector: | VP002-CMV-MCS-3×Flag-EF1-ZsGreen |
| Promoter: | CMV |
| Mutation: | C1099T, C1100A, G1792T, C1793A |
| Titer: | ≥1E+8TU/ml |
| Buffer: | PBS |
| Storage: | -80°C |
| Documents: | Manual-Ready-to-Use Recombinant Lentivirus |
Background
The gene APC encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers, where disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
Optional Services
| Name | Catalog # | Turnaround Time | View |
| Gene Synthesis | S0012 | Quote |  |
| Lentivirus Packaging | S0032 | Quote | |
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