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| Product Category: | Human lentivirus expressing APOE |
| Description: | Premade lentivirus for over-expression of human APOE and control, ready to use format. |
| Gene Name: | Apolipoprotein E |
| Gene Symbol: | APOE |
| Synonyms: | AD2; LPG; APO-E; ApoE4; LDLCQ5 |
| ACCN: | NM_001302691.2 |
| Gene ID: | 348 |
| Vector: | PLVX-PURO |
| Promoter: | CMV |
| Selection Antibiotic: | Puromycin |
| Titer: | ≥1E+8TU/ml |
| Buffer: | PBS |
| Storage: | -80°C |
| Documents: | Manual-Ready-to-Use Recombinant Lentivirus |
Background
The protein encoded by the gene APOE is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
Optional Services
| Name | Catalog # | Turnaround Time | View |
| Gene Synthesis | S0012 | Quote |  |
| Lentivirus Packaging | S0032 | Quote | |
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