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| Product Category: | Human lentivirus expressing CTNNB1 |
| Description: | Premade lentivirus for over-expression of human CTNNB1 and control, ready to use format. |
| Gene Name: | catenin beta 1 |
| Gene Symbol: | CTNNB1 |
| Synonyms: | EVR7; CTNNB; MRD19; NEDSDV; armadillo |
| ACCN: | NM_001904.4 |
| Gene ID: | 1499 |
| Vector: | pCDH-EF1-MCS-CMV-copGFP-T2A-Puro |
| Promoter: | EF1 |
| Selection Antibiotic: | Puromycin |
| Titer: | ≥1E+8TU/ml |
| Buffer: | PBS |
| Storage: | -80°C |
| Documents: | Manual-Ready-to-Use Recombinant Lentivirus |
Background
The protein encoded by the gene CTNNB1 is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.
Optional Services
| Name | Catalog # | Turnaround Time | View |
| Gene Synthesis | S0012 | Quote |  |
| Lentivirus Packaging | S0032 | Quote | |
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