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| Product Category: | Human lentivirus expressing CYP1A1 |
| Description: | Premade lentivirus for over-expression of human CYP1A1 and control, ready to use format. |
| Gene Name: | cytochrome P450 family 1 subfamily A member 1 |
| Gene Symbol: | CYP1A1 |
| Synonyms: | AHH; AHRR; CP11; CYP1; CYPIA1; P1-450; P450-C; P450DX |
| ACCN: | NM_001319217.2 |
| Gene ID: | 1543 |
| Vector: | VP039-CMV-MCS-3×Flag -EF1-mcherry-t2a-Neo |
| Fusion Tag: | Flag |
| Promoter: | CMV |
| Selection Antibiotic: | Neomycin |
| Titer: | ≥1E+8TU/ml |
| Buffer: | PBS |
| Storage: | -80°C |
| Documents: | Manual-Ready-to-Use Recombinant Lentivirus |
Background
The gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Optional Services
| Name | Catalog # | Turnaround Time | View |
| Gene Synthesis | S0012 | Quote |  |
| Lentivirus Packaging | S0032 | Quote | |
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