Your shopping cart is empty!
| Product Category: | Human lentivirus expressing FGFR3 |
| Description: | Premade lentivirus for over-expression of human FGFR3 and control, ready to use format. |
| Gene Name: | fibroblast growth factor receptor 3 |
| Gene Symbol: | FGFR3 |
| Synonyms: | ACH; CEK2; JTK4; CD333; HSFGFR3EX |
| ACCN: | NM_000142.5 |
| Gene ID: | 2261 |
| Vector: | VP007-CMV-MCS-EF1-puro |
| Promoter: | CMV |
| Mutation: | S249C |
| Selection Antibiotic: | Puromycin |
| Titer: | ≥1E+8TU/ml |
| Buffer: | PBS |
| Storage: | -80°C |
| Documents: | Manual-Ready-to-Use Recombinant Lentivirus |
Background
The gene FGFR3 encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.
Optional Services
| Name | Catalog # | Turnaround Time | View |
| Gene Synthesis | S0012 | Quote |  |
| Lentivirus Packaging | S0032 | Quote | |
You may also be interested in:
