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| Product Category: | Human lentivirus expressing FMR1 |
| Description: | Premade lentivirus for over-expression of human FMR1 and control, ready to use format. |
| Gene Name: | fragile X messenger ribonucleoprotein 1 |
| Gene Symbol: | FMR1 |
| Synonyms: | POF; FMRP; POF1; FRAXA |
| ACCN: | NM_002024 |
| Gene ID: | 2332 |
| Vector: | VP007-CMV-MCS-3×Flag-EF1-puro |
| Fusion Tag: | Flag |
| Promoter: | CMV |
| Selection Antibiotic: | Puromycin |
| Titer: | ≥1E+8TU/ml |
| Buffer: | PBS |
| Storage: | -80°C |
| Documents: | Manual-Ready-to-Use Recombinant Lentivirus |
Background
The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.
Optional Services
| Name | Catalog # | Turnaround Time | View |
| Gene Synthesis | S0012 | Quote |  |
| Lentivirus Packaging | S0032 | Quote | |
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