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| Product Category: | Human lentivirus expressing KLF4 |
| Description: | Premade lentivirus for over-expression of human KLF4 and control, ready to use format. |
| Gene Name: | KLF transcription factor 4 |
| Gene Symbol: | KLF4 |
| Synonyms: | EZF; GKLF |
| ACCN: | NM_001314052.2 |
| Gene ID: | 9314 |
| Vector: | VP001-CMV-MCS-EF1-ZsGreen-T2A-PURO |
| Promoter: | CMV |
| Selection Antibiotic: | Puromycin |
| Titer: | ≥1E+8TU/ml |
| Buffer: | PBS |
| Storage: | -80°C |
| Documents: | Manual-Ready-to-Use Recombinant Lentivirus |
Background
The gene KLF4 encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms.
Optional Services
| Name | Catalog # | Turnaround Time | View |
| Gene Synthesis | S0012 | Quote |  |
| Lentivirus Packaging | S0032 | Quote | |
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