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| Product Category: | Human lentivirus expressing MGMT |
| Description: | Premade lentivirus for over-expression of human MGMT and control, ready to use format. |
| Gene Name: | O-6-methylguanine-DNA methyltransferase |
| Gene Symbol: | MGMT |
| Synonyms: | Methylated-DNA--protein-cysteine methyltransferase; 6-O-methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA-alkyltransferase |
| ACCN: | NM_002412.5 |
| Gene ID: | 4255 |
| Vector: | VP030-CMV-MCS-EF1-Blasticidin |
| Promoter: | CMV |
| Selection Antibiotic: | Blasticidin |
| Titer: | ≥1E+8TU/ml |
| Buffer: | PBS |
| Storage: | -80°C |
| Documents: | Manual-Ready-to-Use Recombinant Lentivirus |
Background
Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma.
Optional Services
| Name | Catalog # | Turnaround Time | View |
| Gene Synthesis | S0012 | Quote |  |
| Lentivirus Packaging | S0032 | Quote | |
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