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| Product Category: | Human lentivirus expressing NEDD4L |
| Description: | Premade lentivirus for over-expression of human NEDD4L and control, ready to use format. |
| Gene Name: | NEDD4 like E3 ubiquitin protein ligase |
| Gene Symbol: | NEDD4L |
| Synonyms: | RSP5; PVNH7; NEDD4-2; NEDD4.2; hNEDD4-2 |
| ACCN: | NM_001144967.3 |
| Gene ID: | 23327 |
| Vector: | VP097-CMV-MCS-EF1-EGFP-T2A-PURO |
| Fusion Tag: | Myc |
| Promoter: | CMV |
| Selection Antibiotic: | Puromycin |
| Titer: | ≥1E+8TU/ml |
| Buffer: | PBS |
| Storage: | -80°C |
| Documents: | Manual-Ready-to-Use Recombinant Lentivirus |
Background
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Optional Services
| Name | Catalog # | Turnaround Time | View |
| Gene Synthesis | S0012 | Quote |  |
| Lentivirus Packaging | S0032 | Quote | |
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